Absolutely! At least now
Absolutely! At least now tire manufacturers have specific "ratings" or "models" for low rolling resistance, for the 10 years I had a 2001 Prius there was nothing like that (OK, maybe a couple brands that were horribly performing) and I tried all sorts of tires to balance the mileage and tire performance. I remember one set of tires that took the mileage from 50 to 30. That car had about 360,000 miles on it when I finally traded it in, and it still had the original brake pads. Best automotive investment I ever made.